Vof-16 knockout improves the recovery from hypoxic-ischemic brain damage of neonatal rats
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منابع مشابه
Phenytoin pretreatment prevents hypoxic-ischemic brain damage in neonatal rats.
This study was performed to investigate whether the anticonvulsant phenytoin has neuroprotective effect in a model of hypoxia-ischemia with neonatal rats. The left carotid artery of each rat was ligated, followed by 3 h of hypoxic exposure (8% O2) in a temperature-regulated environment (36 degrees C). Two weeks later, brain damage was assessed by measuring loss of brain hemisphere weight. Pheny...
متن کاملIntraventricular Injection of Human Dental Pulp Stem Cells Improves Hypoxic-Ischemic Brain Damage in Neonatal Rats
OBJECTIVE To investigate the effect of intraventricular injection of human dental pulp stem cells (DPSCs) on hypoxic-ischemic brain damage (HIBD) in neonatal rats. METHODS Thirty-six neonatal rats (postnatal day 7) were assigned to control, HIBD, or HIBD+DPSC groups (n = 12 each group). For induction of HIBD, rats underwent left carotid artery ligation and were exposed to 8% to 10% oxygen for...
متن کاملMK-801 protects the neonatal brain from hypoxic-ischemic damage.
Enhanced synaptic release of excitatory amino acid neurotransmitters may contribute to brain injury from hypoxia-ischemia (Meldrum, 1985; Simon et al., 1984). To examine this hypothesis in neonatal brain we tested MK-80I , a novel noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, using an in vivo experimental model of hypoxic-ischemic forebrain injury (Johnston, 1983). To induce i...
متن کاملCombination of Constraint-Induced Movement Therapy with Electroacupuncture Improves Functional Recovery following Neonatal Hypoxic-Ischemic Brain Injury in Rats
Aim Neonatal hypoxic-ischemia (HI) due to insufficient oxygen supply and blood flow during the prenatal and postnatal periods can cause cerebral palsy, a serious developmental condition. The purpose of this study was to investigate the efficacy of combining constraint-induced movement therapy (CIMT) and electroacupuncture to treat rat neonatal HI brain injury. Methods The left common carotid ...
متن کاملEffect of hyperbaric oxygen on neurological recovery of neonatal rats following hypoxic-ischemic brain damage and its underlying mechanism.
OBJECTIVE To investigate the mechanism underlying the effect of hyperbaric oxygen (HBO) on hypoxic/ischemic brain damage (HIBD) in a neonatal rat model. METHODS A total of 30 neonatal SD rats aged 7 days were randomly assigned into control group, HIBD group and HBO group (n=10 per group). Following HIBD modeling in neonatal rats, HBO treatment was performed for consecutive 7 days. Immunohisto...
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ژورنال
عنوان ژورنال: Brain Research
سال: 2020
ISSN: 0006-8993
DOI: 10.1016/j.brainres.2020.147070